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Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
In this study, we characterized the chemical modifications in the monoclonal antibody (IgG(2)) aggregates generated under various conditions, including mechanical, chemical, and thermal stress treatment, to provide insight into the mechanism of protein aggregation and the types of aggregate produced...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137086/ https://ncbi.nlm.nih.gov/pubmed/21518762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160440 |
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