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Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
In this study, we characterized the chemical modifications in the monoclonal antibody (IgG(2)) aggregates generated under various conditions, including mechanical, chemical, and thermal stress treatment, to provide insight into the mechanism of protein aggregation and the types of aggregate produced...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137086/ https://ncbi.nlm.nih.gov/pubmed/21518762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160440 |
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