Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses

Aggregation of biotherapeutics has the potential to induce an immunogenic response. Here, we show that aggregated therapeutic antibodies, previously generated and determined to contain a variety of attributes (Joubert, M. K., Luo, Q., Nashed-Samuel, Y., Wypych, J., and Narhi, L. O. (2011) J. Biol. C...

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Bibliografiset tiedot
Päätekijät: Joubert, Marisa K., Hokom, Martha, Eakin, Catherine, Zhou, Lei, Deshpande, Meghana, Baker, Matthew P., Goletz, Theresa J., Kerwin, Bruce A., Chirmule, Naren, Narhi, Linda O., Jawa, Vibha
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408134/
https://ncbi.nlm.nih.gov/pubmed/22584577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.330902
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