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Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
The development of therapeutic proteins requires the understanding of the relationship between the dose, exposure, efficacy, and toxicity of these molecules. Several intrinsic and extrinsic factors contribute to the challenges for measuring therapeutic proteins in a precise and accurate manner. In a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326159/ https://ncbi.nlm.nih.gov/pubmed/22407289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9340-y |
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