Utility of a Bayesian Mathematical Model to Predict the Impact of Immunogenicity on Pharmacokinetics of Therapeutic Proteins

The impact of an anti-drug antibody (ADA) response on pharmacokinetic (PK) of a therapeutic protein (TP) requires an in-depth understanding of both PK parameters and ADA characteristics. The ADA and PK bioanalytical assays have technical limitations due to high circulating levels of TP and ADA, resp...

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Vydáno v:AAPS J
Hlavní autoři: Kathman, Steven, Thway, Theingi M., Zhou, Lei, Lee, Stephanie, Yu, Steven, Ma, Mark, Chirmule, Naren, Jawa, Vibha
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779091/
https://ncbi.nlm.nih.gov/pubmed/26786568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9853-2
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