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Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

The development of therapeutic proteins requires the understanding of the relationship between the dose, exposure, efficacy, and toxicity of these molecules. Several intrinsic and extrinsic factors contribute to the challenges for measuring therapeutic proteins in a precise and accurate manner. In a...

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Bibliografski detalji
Glavni autori: Chirmule, Narendra, Jawa, Vibha, Meibohm, Bernd
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326159/
https://ncbi.nlm.nih.gov/pubmed/22407289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9340-y
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