Immunogenicity of protein therapeutics: The key causes, consequences and challenges

Por Baker, Matthew P, Reynolds, Helen M, Lumicisi, Brooke, Bryson, Christine J
Publicado em 2010

Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy and Reduced Immunogenicity

Por Holgate, Robert G. E., Weldon, Richard, Jones, Timothy D., Baker, Matthew P.
Publicado no PLoS One (2015)

A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors

Por Webster, Carl I., Bryson, Christine J., Cloake, Edward A., Jones, Tim D., Austin, Mark J., Karle, Anette C., Spindeldreher, Sebastian, Lowe, David C., Baker, Matthew P.
Publicado no MAbs (2016)

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4(+) T cell epitopes and its use as an immunotoxin warhead

Por Jones, Tim D., Hearn, Arron R., Holgate, Robert G.E., Kozub, Dorota, Fogg, Mark H., Carr, Francis J., Baker, Matthew P., Lacadena, Javier, Gehlsen, Kurt R.
Publicado no Protein Eng Des Sel (2016)

Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses

Por Joubert, Marisa K., Hokom, Martha, Eakin, Catherine, Zhou, Lei, Deshpande, Meghana, Baker, Matthew P., Goletz, Theresa J., Kerwin, Bruce A., Chirmule, Naren, Narhi, Linda O., Jawa, Vibha
Publicado em 2012

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics

Por Joubert, Marisa K., Deshpande, Meghana, Yang, Jane, Reynolds, Helen, Bryson, Christine, Fogg, Mark, Baker, Matthew P., Herskovitz, Jonathan, Goletz, Theresa J., Zhou, Lei, Moxness, Michael, Flynn, Gregory C., Narhi, Linda O., Jawa, Vibha
Publicado no PLoS One (2016)

The INNs and outs of antibody nonproprietary names

Por Jones, Tim D., Carter, Paul J., Plückthun, Andreas, Vásquez, Max, Holgate, Robert G.E., Hötzel, Isidro, Popplewell, Andrew G., Parren, Paul W.H.I., Enzelberger, Markus, Rademaker, Hendrik J., Clark, Michael R., Lowe, David C., Dahiyat, Bassil I., Smith, Victoria, Lambert, John M., Wu, Herren, Reilly, Mary, Haurum, John S., Dübel, Stefan, Huston, James S., Schirrmann, Thomas, Janssen, Richard A.J., Steegmaier, Martin, Gross, Jane A., Bradbury, Andrew R.M., Burton, Dennis R., Dimitrov, Dimiter S., Chester, Kerry A., Glennie, Martin J., Davies, Julian, Walker, Adam, Martin, Steve, McCafferty, John, Baker, Matthew P.
Publicado no MAbs (2015)