Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting

An IgG2 monoclonal antibody (mAb) solution was subjected to stirring, generating high concentrations of nanometer and subvisible particles, which were then successfully size enriched into different size bins by low speed centrifugation or a combination of gravitational sedimentation and Fluorescence...

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Detaylı Bibliyografya
Yayımlandı:J Pharm Sci
Asıl Yazarlar: Telikepalli, Srivalli, Shinogle, Heather E., Thapa, Prem S., Kim, Jae Hyun, Deshpande, Meghana, Jawa, Vibha, Middaugh, C. Russell, Narhi, Linda O., Joubert, Marisa K., Volkin, David B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448733/
https://ncbi.nlm.nih.gov/pubmed/25753756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24379
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