Classification and Characterization of Therapeutic Antibody Aggregates

A host of diverse stress techniques was applied to a monoclonal antibody (IgG(2)) to yield protein particles with varying attributes and morphologies. Aggregated solutions were evaluated for percent aggregation, particle counts, size distribution, morphology, changes in secondary and tertiary struct...

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Detaylı Bibliyografya
Asıl Yazarlar: Joubert, Marisa K., Luo, Quanzhou, Nashed-Samuel, Yasser, Wypych, Jette, Narhi, Linda O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137085/
https://ncbi.nlm.nih.gov/pubmed/21454532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160457
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