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Classification and Characterization of Therapeutic Antibody Aggregates
A host of diverse stress techniques was applied to a monoclonal antibody (IgG(2)) to yield protein particles with varying attributes and morphologies. Aggregated solutions were evaluated for percent aggregation, particle counts, size distribution, morphology, changes in secondary and tertiary struct...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137085/ https://ncbi.nlm.nih.gov/pubmed/21454532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160457 |
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