Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers

Although the formation of β-amyloid (Aβ) deposits in the brain is a hallmark of Alzheimer disease (AD), the soluble oligomers rather than the mature amyloid fibrils most likely contribute to Aβ toxicity and neurodegeneration. Thus, the discovery of agents targeting soluble Aβ oligomers is highly des...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Barr, Renae K., Verdile, Giuseppe, Wijaya, Linda K., Morici, Michael, Taddei, Kevin, Gupta, Veer B., Pedrini, Steve, Jin, Liang, Nicolazzo, Joseph A., Knock, Erin, Fraser, Paul E., Martins, Ralph N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705376/
https://ncbi.nlm.nih.gov/pubmed/26538562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679993
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