Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers

Although the formation of β-amyloid (Aβ) deposits in the brain is a hallmark of Alzheimer disease (AD), the soluble oligomers rather than the mature amyloid fibrils most likely contribute to Aβ toxicity and neurodegeneration. Thus, the discovery of agents targeting soluble Aβ oligomers is highly des...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Barr, Renae K., Verdile, Giuseppe, Wijaya, Linda K., Morici, Michael, Taddei, Kevin, Gupta, Veer B., Pedrini, Steve, Jin, Liang, Nicolazzo, Joseph A., Knock, Erin, Fraser, Paul E., Martins, Ralph N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705376/
https://ncbi.nlm.nih.gov/pubmed/26538562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679993
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