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Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

In this study, we characterized the chemical modifications in the monoclonal antibody (IgG(2)) aggregates generated under various conditions, including mechanical, chemical, and thermal stress treatment, to provide insight into the mechanism of protein aggregation and the types of aggregate produced...

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Main Authors: Luo, Quanzhou, Joubert, Marisa K., Stevenson, Riki, Ketchem, Randal R., Narhi, Linda O., Wypych, Jette
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137086/
https://ncbi.nlm.nih.gov/pubmed/21518762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160440
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