Biological Relevance and Therapeutic Potential of the Hypusine Modification System

Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial regulator in cancer, infections, and inflammation. Although its contribution in translational regulation of proline repeat-rich proteins has been sufficiently demonstrated, its biological role in higher eu...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Pällmann, Nora, Braig, Melanie, Sievert, Henning, Preukschas, Michael, Hermans-Borgmeyer, Irm, Schweizer, Michaela, Nagel, Claus Henning, Neumann, Melanie, Wild, Peter, Haralambieva, Eugenia, Hagel, Christian, Bokemeyer, Carsten, Hauber, Joachim, Balabanov, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513096/
https://ncbi.nlm.nih.gov/pubmed/26037925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664490
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