A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that control translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently,...

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Bibliografische gegevens
Hoofdauteurs: Sievert, Henning, Pällmann, Nora, Miller, Katharine K., Hermans-Borgmeyer, Irm, Venz, Simone, Sendoel, Ataman, Preukschas, Michael, Schweizer, Michaela, Boettcher, Steffen, Janiesch, P. Christoph, Streichert, Thomas, Walther, Reinhard, Hengartner, Michael O., Manz, Markus G., Brümmendorf, Tim H., Bokemeyer, Carsten, Braig, Melanie, Hauber, Joachim, Duncan, Kent E., Balabanov, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Limited 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107325/
https://ncbi.nlm.nih.gov/pubmed/24832488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014449
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