A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that control translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently,...

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Détails bibliographiques
Auteurs principaux: Sievert, Henning, Pällmann, Nora, Miller, Katharine K., Hermans-Borgmeyer, Irm, Venz, Simone, Sendoel, Ataman, Preukschas, Michael, Schweizer, Michaela, Boettcher, Steffen, Janiesch, P. Christoph, Streichert, Thomas, Walther, Reinhard, Hengartner, Michael O., Manz, Markus G., Brümmendorf, Tim H., Bokemeyer, Carsten, Braig, Melanie, Hauber, Joachim, Duncan, Kent E., Balabanov, Stefan
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Limited 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107325/
https://ncbi.nlm.nih.gov/pubmed/24832488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014449
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