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Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1
Hydroxyl radicals induce hinge cleavage in a human IgG1 molecule via initial radical formation at the first hinge Cys(231) followed by electron transfer to the upper hinge residues. To enable engineering of a stable monoclonal antibody hinge, we investigated the role of the hinge His(229) residue us...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881791/ https://ncbi.nlm.nih.gov/pubmed/20304919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108597 |
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