Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1

Hydroxyl radicals induce hinge cleavage in a human IgG1 molecule via initial radical formation at the first hinge Cys(231) followed by electron transfer to the upper hinge residues. To enable engineering of a stable monoclonal antibody hinge, we investigated the role of the hinge His(229) residue us...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Yates, Zac, Gunasekaran, Kannan, Zhou, Hongxing, Hu, Zhonghua, Liu, Zhi, Ketchem, Randal R., Yan, Boxu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881791/
https://ncbi.nlm.nih.gov/pubmed/20304919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108597
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker