Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

Upper hinge is vulnerable to radical attacks that result in breakage of the heavy-light chain linkage and cleavage of the hinge of an IgG1. To further explore mechanisms responsible for the radical induced hinge degradation, nine mutants were designed to determine the roles that the upper hinge Asp...

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Bibliografiska uppgifter
Huvudupphovsmän: Yan, Boxu, Boyd, Daniel, Kaschak, Timothy, Tsukuda, Joni, Shen, Amy, Lin, Yuwen, Chung, Shan, Gupta, Priyanka, Kamath, Amrita, Wong, Anne, Vernes, Jean-Michel, Meng, Gloria Y., Totpal, Klara, Schaefer, Gabriele, Jiang, Guoying, Nogal, Bartek, Emery, Craig, Vanderlaan, Martin, Carter, Paul, Harris, Reed, Amanullah, Ashraf
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Protein Synthesis and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325591/
https://ncbi.nlm.nih.gov/pubmed/22203673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311811
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