Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

Upper hinge is vulnerable to radical attacks that result in breakage of the heavy-light chain linkage and cleavage of the hinge of an IgG1. To further explore mechanisms responsible for the radical induced hinge degradation, nine mutants were designed to determine the roles that the upper hinge Asp...

詳細記述

保存先:
書誌詳細
主要な著者: Yan, Boxu, Boyd, Daniel, Kaschak, Timothy, Tsukuda, Joni, Shen, Amy, Lin, Yuwen, Chung, Shan, Gupta, Priyanka, Kamath, Amrita, Wong, Anne, Vernes, Jean-Michel, Meng, Gloria Y., Totpal, Klara, Schaefer, Gabriele, Jiang, Guoying, Nogal, Bartek, Emery, Craig, Vanderlaan, Martin, Carter, Paul, Harris, Reed, Amanullah, Ashraf
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
Protein Synthesis and Degradation
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325591/
https://ncbi.nlm.nih.gov/pubmed/22203673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311811
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料