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Evading pre-existing anti-hinge antibody binding by hinge engineering

Antigen-binding fragments (Fab) and F(ab′)(2) antibodies serve as alternative formats to full-length anti-bodies in therapeutic and immune assays. They provide the advantage of small size, short serum half-life, and lack of effector function. Several proteases associated with invasive diseases are k...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Kim, Hok Seon, Kim, Ingrid, Zheng, Linda, Vernes, Jean-Michel, Meng, Y. Gloria, Spiess, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098439/
https://ncbi.nlm.nih.gov/pubmed/27606571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1219006
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