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Evading pre-existing anti-hinge antibody binding by hinge engineering
Antigen-binding fragments (Fab) and F(ab′)(2) antibodies serve as alternative formats to full-length anti-bodies in therapeutic and immune assays. They provide the advantage of small size, short serum half-life, and lack of effector function. Several proteases associated with invasive diseases are k...
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| Publicado en: | MAbs |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098439/ https://ncbi.nlm.nih.gov/pubmed/27606571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1219006 |
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