Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting

Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome pre-existing Abs. Given the complexity of Ab production, overcoming pre-existing Abs will require broad immune targeting. We generated a mouse model of...

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Bibliografiske detaljer
Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Velazquez, Victoria M., Meadows, Aaron S., Pineda, Ricardo J., Camboni, Marybeth, McCarty, Douglas M., Fu, Haiyan
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363314/
https://ncbi.nlm.nih.gov/pubmed/28345001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.01.003
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