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Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity
Vectors based on adeno-associated viruses (AAV) have shown considerable promise in both preclinical models and increasingly in clinical trials. However, one formidable challenge is pre-existing immunity due to widespread exposure to numerous AAV variants and serotypes within the human population, wh...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Research Foundation
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207363/ https://ncbi.nlm.nih.gov/pubmed/22065962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2011.00204 |
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