Characterization of the basic charge variants of a human IgG1: Effect of copper concentration in cell culture media

We report a case study of an IgG1 with a unique basic charge variant profile caused by C-terminal proline amidation on either one or two heavy chains. The proline amidation was sensitive to copper ion concentration in the production media during cell culture: the higher the Cu(2+) ion concentration,...

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Detalhes bibliográficos
Main Authors: Kaschak, Timothy, Boyd, Daniel, Lu, Franklin, Derfus, Gayle, Kluck, Brian, Nogal, Bartek, Emery, Craig, Summers, Christie, Zheng, Kai, Bayer, Robert, Amanullah, Ashraf, Yan, Boxu
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242844/
https://ncbi.nlm.nih.gov/pubmed/22123059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.17959
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