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Characterization of the basic charge variants of a human IgG1: Effect of copper concentration in cell culture media
We report a case study of an IgG1 with a unique basic charge variant profile caused by C-terminal proline amidation on either one or two heavy chains. The proline amidation was sensitive to copper ion concentration in the production media during cell culture: the higher the Cu(2+) ion concentration,...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242844/ https://ncbi.nlm.nih.gov/pubmed/22123059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.17959 |
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