Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest

While many antibody therapeutics are formulated at low concentration (~10–20 mg/mL) for intravenous administration, high concentration (> 100 mg/mL) formulations may be required for subcutaneous delivery in certain clinical indications. For such high concentration formulations, product color is m...

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Hlavní autoři: Derfus, Gayle E, Dizon-Maspat, Jemelle, Broddrick, Jared T, Velayo, Arleene C, Toschi, Josh D, Santuray, Rodell T, Hsu, Stephen K, Winter, Charles M, Krishnan, Rajesh, Amanullah, Ashraf
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011912/
https://ncbi.nlm.nih.gov/pubmed/24552690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28257
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