Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody could be partially resolved into structurally distinct forms caused by multiple disulfide bond structures. In addition to the presently accepte...

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Bibliografiska uppgifter
Huvudupphovsmän: Wypych, Jette, Li, Ming, Guo, Amy, Zhang, Zhongqi, Martinez, Theresa, Allen, Martin J., Fodor, Szilan, Kelner, Drew N., Flynn, Gregory C., Liu, Yaoqing Diana, Bondarenko, Pavel V., Ricci, Margaret Speed, Dillon, Thomas M., Balland, Alain
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259661/
https://ncbi.nlm.nih.gov/pubmed/18339624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709987200
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