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Breaking the Light and Heavy Chain Linkage of Human Immunoglobulin G1 (IgG1) by Radical Reactions

We report that the production of hydrogen peroxide by radical chain reductions of molecular oxygen into water in buffers leads to hinge degradation of a human IgG1 under thermal incubation conditions. The production of the hydrogen peroxide can be accelerated by superoxide dismutase or redox active...

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Autors principals: Yan, Boxu, Boyd, Daniel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137043/
https://ncbi.nlm.nih.gov/pubmed/21606498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255026
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