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Breaking the Light and Heavy Chain Linkage of Human Immunoglobulin G1 (IgG1) by Radical Reactions

We report that the production of hydrogen peroxide by radical chain reductions of molecular oxygen into water in buffers leads to hinge degradation of a human IgG1 under thermal incubation conditions. The production of the hydrogen peroxide can be accelerated by superoxide dismutase or redox active...

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Bibliografiska uppgifter
Huvudupphovsmän: Yan, Boxu, Boyd, Daniel
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137043/
https://ncbi.nlm.nih.gov/pubmed/21606498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255026
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