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Cysteine Racemization on IgG Heavy and Light Chains
Under basic pH conditions, the heavy chain 220-light chain 214 (H220-L214) disulfide bond, found in the flexible hinge region of an IgG1, can convert to a thioether. Similar conditions also result in racemization of the H220 cysteine. Here, we report that racemization occurs on both H220 and L214 on...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843047/ https://ncbi.nlm.nih.gov/pubmed/24142697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506915 |
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