Cysteine Racemization on IgG Heavy and Light Chains

Under basic pH conditions, the heavy chain 220-light chain 214 (H220-L214) disulfide bond, found in the flexible hinge region of an IgG1, can convert to a thioether. Similar conditions also result in racemization of the H220 cysteine. Here, we report that racemization occurs on both H220 and L214 on...

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Bibliographic Details
Main Authors: Zhang, Qingchun, Flynn, Gregory C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843047/
https://ncbi.nlm.nih.gov/pubmed/24142697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506915
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