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Human IgG1 Hinge Fragmentation as the Result of H(2)O(2)-mediated Radical Cleavage
Hinge cleavage of a recombinant human IgG1 antibody, generated during production in a Chinese hamster ovary cell culture, was observed in the purified material. The cleavage products could be reproduced by incubation of the antibody with H(2)O(2) and featured complementary ladders of the C- and N-te...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790968/ https://ncbi.nlm.nih.gov/pubmed/19850927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064147 |
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