The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation

Transparency in the lens is accomplished by the dense packing and short-range order interactions of the crystallin proteins in fiber cells lacking organelles. These features are accompanied by a lack of protein turnover, leaving lens proteins susceptible to a number of damaging modifications and agg...

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Опубликовано в: :J Biol Chem
Главные авторы: Warmack, Rebeccah A., Shawa, Harrison, Liu, Kate, Lopez, Katia, Loo, Joseph A., Horwitz, Joseph, Clarke, Steven G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Protein Synthesis and Degradation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690693/
https://ncbi.nlm.nih.gov/pubmed/31239355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009052
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