Misfolded Proteins Induce Aggregation of the Lectin Yos9

A substantial fraction of nascent proteins delivered into the endoplasmic reticulum (ER) never reach their native conformations. Eukaryotes use a series of complementary pathways to efficiently recognize and dispose of these terminally misfolded proteins. In this process, collectively termed ER-asso...

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Bibliographic Details
Main Authors: Smith, Melanie H., Rodriguez, Edwin H., Weissman, Jonathan S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162170/
https://ncbi.nlm.nih.gov/pubmed/25086047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.583344
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