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A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β
Deoxynucleotide misincorporation efficiencies can span a wide 10(4)-fold range, from ~10(−2) to ~10(−6), depending principally on polymerase (pol) identity and DNA sequence context. We have addressed DNA pol fidelity mechanisms from a transition-state (TS) perspective using our “tool-kit” of dATP-an...
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| Publicat a: | Biochemistry |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6681824/ https://ncbi.nlm.nih.gov/pubmed/30839203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00087 |
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