Transition State in DNA Polymerase β Catalysis: Rate-Limiting Chemistry Altered by Base-Pair Configuration

[Image: see text] Kinetics studies of dNTP analogues having pyrophosphate-mimicking β,γ-pCXYp leaving groups with variable X and Y substitution reveal striking differences in the chemical transition-state energy for DNA polymerase β that depend on all aspects of base-pairing configurations, includin...

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Detalhes bibliográficos
Main Authors: Oertell, Keriann, Chamberlain, Brian T., Wu, Yue, Ferri, Elena, Kashemirov, Boris A., Beard, William A., Wilson, Samuel H., McKenna, Charles E., Goodman, Myron F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985788/
https://ncbi.nlm.nih.gov/pubmed/24580380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500101z
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