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Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity
What is the free energy source enabling high-fidelity DNA polymerases (pols) to favor incorporation of correct over incorrect base pairs by 10(3)- to 10(4)-fold, corresponding to free energy differences of ΔΔG(inc) ∼ 5.5–7 kcal/mol? Standard ΔΔG° values (∼0.3 kcal/mol) calculated from melting temper...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4843490/ https://ncbi.nlm.nih.gov/pubmed/27044101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600279113 |
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