Effect of β,γ-CHF and β,γ-CHCl dGTP halogen atom stereochemistry on the transition state of DNA polymerase β()

Recently, we synthesized the first individual β,γ-CHX dGTP diastereomers ((R)- or (S)-CHX; X = F or Cl), and determined their structures in ternary complexes with pol β. We now report stereospecificity by pol β on the mixed β,γ-CHX diastereomer pairs using NMR and on the separate diastereomers using...

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Autores principales: Oertell, Keriann, Wu, Yue, Zakharova, Valeria M., Kashemirov, Boris A., Shock, David D., Beard, William A., Wilson, Samuel H., McKenna, Charles E., Goodman, Myron F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548995/
https://ncbi.nlm.nih.gov/pubmed/23043620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3010335
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