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Effect of β,γ-CHF and β,γ-CHCl dGTP halogen atom stereochemistry on the transition state of DNA polymerase β()
Recently, we synthesized the first individual β,γ-CHX dGTP diastereomers ((R)- or (S)-CHX; X = F or Cl), and determined their structures in ternary complexes with pol β. We now report stereospecificity by pol β on the mixed β,γ-CHX diastereomer pairs using NMR and on the separate diastereomers using...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548995/ https://ncbi.nlm.nih.gov/pubmed/23043620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3010335 |
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