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Synthesis of 8-oxo-dGTP and its β,γ-CH(2)-, β, γ-CHF-, and β, γ-CF(2)- analogues
Three novel 8-oxo-dGTP bisphosphonate analogues of 3 in which the bridging β,γ-oxygen is replaced by a methylene, fluoromethylene or difluoromethylene group (4–6, respectively) have been synthesized from 8-oxo-dGMP 2 by reaction of its morpholine 5’-phosphoramidate 14 or preferably, its N-methylimid...
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7951955/ https://ncbi.nlm.nih.gov/pubmed/33716328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2021.152890 |
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