A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β

Deoxynucleotide misincorporation efficiencies can span a wide 10(4)-fold range, from ~10(−2) to ~10(−6), depending principally on polymerase (pol) identity and DNA sequence context. We have addressed DNA pol fidelity mechanisms from a transition-state (TS) perspective using our “tool-kit” of dATP-an...

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Publicado en:Biochemistry
Autores principales: Oertell, Keriann, Florián, Jan, Haratipour, Pouya, Crans, Debbie C., Kashemirov, Boris A., Wilson, Samuel H., McKenna, Charles E., Goodman, Myron F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681824/
https://ncbi.nlm.nih.gov/pubmed/30839203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00087
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