Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding

Chemotherapy and radiation (C,R) are more effective in wild type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with (C,R). Zinc metallochaperones (ZMCs) are a new class of mutant p53 reactivators that restore WT structure an...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cancer Ther
Main Authors: Zaman, Saif, Yu, Xin, Bencivenga, Anthony F., Blanden, Adam R., Liu, Yue, Withers, Tracy, Na, Bing, Blayney, Alan J., Gilleran, John, Boothman, David A., Loh, Stewart N., Kimball, S. David, Carpizo, Darren R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677634/
https://ncbi.nlm.nih.gov/pubmed/31196889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1080
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki