Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding

Chemotherapy and radiation (C,R) are more effective in wild type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with (C,R). Zinc metallochaperones (ZMCs) are a new class of mutant p53 reactivators that restore WT structure an...

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Bibliografski detalji
Izdano u:Mol Cancer Ther
Glavni autori: Zaman, Saif, Yu, Xin, Bencivenga, Anthony F., Blanden, Adam R., Liu, Yue, Withers, Tracy, Na, Bing, Blayney, Alan J., Gilleran, John, Boothman, David A., Loh, Stewart N., Kimball, S. David, Carpizo, Darren R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677634/
https://ncbi.nlm.nih.gov/pubmed/31196889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1080
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