Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). We investigated the mechanism by which ZMC1 reactivates p53-R175H and provide evidence that ZMC1: 1) restores WT structure by functioning as a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Xin, Blanden, Adam R., Narayanan, Sumana, Jayakumar, Lalithapriya, Lubin, David, Augeri, David, David Kimball, S., Loh, Stewart N., Carpizo, Darren R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253404/
https://ncbi.nlm.nih.gov/pubmed/25294809
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