Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding

Chemotherapy and radiation (C,R) are more effective in wild type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with (C,R). Zinc metallochaperones (ZMCs) are a new class of mutant p53 reactivators that restore WT structure an...

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書誌詳細
出版年:Mol Cancer Ther
主要な著者: Zaman, Saif, Yu, Xin, Bencivenga, Anthony F., Blanden, Adam R., Liu, Yue, Withers, Tracy, Na, Bing, Blayney, Alan J., Gilleran, John, Boothman, David A., Loh, Stewart N., Kimball, S. David, Carpizo, Darren R.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677634/
https://ncbi.nlm.nih.gov/pubmed/31196889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1080
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