Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding

Chemotherapy and radiation (C,R) are more effective in wild type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with (C,R). Zinc metallochaperones (ZMCs) are a new class of mutant p53 reactivators that restore WT structure an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Zaman, Saif, Yu, Xin, Bencivenga, Anthony F., Blanden, Adam R., Liu, Yue, Withers, Tracy, Na, Bing, Blayney, Alan J., Gilleran, John, Boothman, David A., Loh, Stewart N., Kimball, S. David, Carpizo, Darren R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677634/
https://ncbi.nlm.nih.gov/pubmed/31196889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1080
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados