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Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer
Tumor protein p53 (TP53) is the most commonly mutated gene in human cancer. The majority of mutations are missense, and generate a defective protein that is druggable. Yet, for decades, the small-molecule restoration of wild-type (WT) p53 function in mutant p53 tumors (so-called p53 mutant ‘reactiva...
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| Vydáno v: | Drug Discov Today |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922747/ https://ncbi.nlm.nih.gov/pubmed/26205328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2015.07.006 |
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