Cargando...
Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer
Tumor protein p53 (TP53) is the most commonly mutated gene in human cancer. The majority of mutations are missense, and generate a defective protein that is druggable. Yet, for decades, the small-molecule restoration of wild-type (WT) p53 function in mutant p53 tumors (so-called p53 mutant ‘reactiva...
Gardado en:
| Publicado en: | Drug Discov Today |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922747/ https://ncbi.nlm.nih.gov/pubmed/26205328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2015.07.006 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|