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Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer
Tumor protein p53 (TP53) is the most commonly mutated gene in human cancer. The majority of mutations are missense, and generate a defective protein that is druggable. Yet, for decades, the small-molecule restoration of wild-type (WT) p53 function in mutant p53 tumors (so-called p53 mutant ‘reactiva...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Drug Discov Today |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922747/ https://ncbi.nlm.nih.gov/pubmed/26205328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2015.07.006 |
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