Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer

Tumor protein p53 (TP53) is the most commonly mutated gene in human cancer. The majority of mutations are missense, and generate a defective protein that is druggable. Yet, for decades, the small-molecule restoration of wild-type (WT) p53 function in mutant p53 tumors (so-called p53 mutant ‘reactiva...

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Udgivet i:Drug Discov Today
Main Authors: Blanden, Adam R., Yu, Xin, Loh, Stewart N., Levine, Arnold J., Carpizo, Darren R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922747/
https://ncbi.nlm.nih.gov/pubmed/26205328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2015.07.006
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