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Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

Restoration of wild-type structure and function to mutant p53 with a small molecule (hereafter referred to as “reactivating” mutant p53) is one of the holy grails in cancer therapeutics. The majority of TP53 mutations are missense which generate a defective protein that is targetable. We are current...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Kogan, Samuel, Carpizo, Darren R.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025018/
https://ncbi.nlm.nih.gov/pubmed/29843463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10060166
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