Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53

Small-molecule restoration of wild-type structure and function to mutant p53 (so-called mutant reactivation) is a highly sought-after goal in cancer drug development. We previously discovered that small-molecule zinc chelators called zinc metallochaperones (ZMCs) reactivate mutant p53 by restoring z...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Yu, Xin, Blanden, Adam, Tsang, Ashley T., Zaman, Saif, Liu, Yue, Gilleran, John, Bencivenga, Anthony F., Kimball, S. David, Loh, Stewart N., Carpizo, Darren R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438133/
https://ncbi.nlm.nih.gov/pubmed/28320780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.107409
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