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Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53
Small-molecule restoration of wild-type structure and function to mutant p53 (so-called mutant reactivation) is a highly sought-after goal in cancer drug development. We previously discovered that small-molecule zinc chelators called zinc metallochaperones (ZMCs) reactivate mutant p53 by restoring z...
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| Udgivet i: | Mol Pharmacol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438133/ https://ncbi.nlm.nih.gov/pubmed/28320780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.107409 |
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