טוען...
Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore
p53 is a Zn(2+)-dependent tumor suppressor inactivated in >50% of human cancers. The most common mutation, R175H, inactivates p53 by reducing its affinity for the essential zinc ion, leaving the mutant protein unable to bind the metal in the low [Zn(2+)](free) environment of the cell. The explora...
שמור ב:
| הוצא לאור ב: | Mol Pharmacol |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4407733/ https://ncbi.nlm.nih.gov/pubmed/25710967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097550 |
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