Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore

p53 is a Zn(2+)-dependent tumor suppressor inactivated in >50% of human cancers. The most common mutation, R175H, inactivates p53 by reducing its affinity for the essential zinc ion, leaving the mutant protein unable to bind the metal in the low [Zn(2+)](free) environment of the cell. The explora...

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Udgivet i:Mol Pharmacol
Main Authors: Blanden, Adam R., Yu, Xin, Wolfe, Aaron J., Gilleran, John A., Augeri, David J., O’Dell, Ryan S., Olson, Eric C., Kimball, S. David, Emge, Thomas J., Movileanu, Liviu, Carpizo, Darren R., Loh, Stewart N.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407733/
https://ncbi.nlm.nih.gov/pubmed/25710967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097550
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