Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). We investigated the mechanism by which ZMC1 reactivates p53-R175H and provide evidence that ZMC1: 1) restores WT structure by functioning as a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Yu, Xin, Blanden, Adam R., Narayanan, Sumana, Jayakumar, Lalithapriya, Lubin, David, Augeri, David, David Kimball, S., Loh, Stewart N., Carpizo, Darren R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2014
Ämnen:
Priority Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253404/
https://ncbi.nlm.nih.gov/pubmed/25294809
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk