Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in Apc (Δ716) mutant mice

Iodothyronine deiodinase 2 (DIO2) converts the prohormone thyroxine (T4) to bioactive T3 in peripheral tissues and thereby regulates local thyroid hormone (TH) levels. Although epidemiologic studies suggest the contribution of TH to the progression of colorectal cancer (CRC), the role of DIO2 in CRC...

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Vydáno v:Cancer Sci
Hlavní autoři: Kojima, Yasushi, Kondo, Yuriko, Fujishita, Teruaki, Mishiro‐Sato, Emi, Kajino‐Sakamoto, Rie, Taketo, Makoto Mark, Aoki, Masahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676103/
https://ncbi.nlm.nih.gov/pubmed/31215118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14100
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