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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc(Δ716) mice
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth via mTOR complex 1 (mTORC1), whose activation has been implicated in many human cancers. However, mTORC1's status in gastrointestinal tumors has not been characterized thoroughly. We have found that...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533226/ https://ncbi.nlm.nih.gov/pubmed/18768809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800041105 |
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